Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction.

Matteoli, Gianluca; Mazzini, Elisa; Iliev, Iliyan D; Mileti, Erika; Fallarino, Francesca; Puccetti, Paolo; Chieppa, Marcello; Rescigno, Maria

Matteoli, Gianluca; Mazzini, Elisa; Iliev, Iliyan D; Mileti, Erika; Fallarino, Francesca; Puccetti, Paolo; Chieppa, Marcello; Rescigno, Maria.

Affiliation

Matteoli G; Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy.

Gut ; 59(5): 595-604, 2010 May.

Article in En | MEDLINE | ID: mdl-20427394

Subject(s)

Antigens, CD/analysis; Dendritic Cells/enzymology; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Integrin alpha Chains/analysis; Intestinal Mucosa/immunology; T-Lymphocytes, Regulatory/immunology; Administration, Oral; Animals; Cell Differentiation/immunology; Cells, Cultured; Colitis/immunology; Dendritic Cells/drug effects; Dendritic Cells/immunology; Enzyme Inhibitors/pharmacology; Humans; Immune Tolerance/drug effects; Immune Tolerance/immunology; Immunity, Mucosal; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors; Indoleamine-Pyrrole 2,3,-Dioxygenase/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin/administration & dosage; Ovalbumin/immunology; T-Lymphocyte Subsets/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Antigens, CD / T-Lymphocytes, Regulatory / Integrin alpha Chains / Indoleamine-Pyrrole 2,3,-Dioxygenase / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Gut Year: 2010 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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