Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.

Wiles, Karen G; Panizzi, Peter; Kroh, Heather K; Bock, Paul E

Wiles, Karen G; Panizzi, Peter; Kroh, Heather K; Bock, Paul E.

Affiliation

Wiles KG; Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

J Biol Chem ; 285(27): 21153-64, 2010 Jul 02.

Article in En | MEDLINE | ID: mdl-20435890

Subject(s)

Bacterial Proteins/metabolism; Fibrinolysin/biosynthesis; Fibrinolysin/metabolism; Fibrinolysis/physiology; Metalloendopeptidases/metabolism; Plasminogen/metabolism; Streptococcus agalactiae/metabolism; Streptokinase/metabolism; Amino Acid Sequence; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Conserved Sequence; Humans; Kinetics; Metalloendopeptidases/chemistry; Metalloendopeptidases/genetics; Protein Binding; Streptokinase/chemistry; Streptokinase/genetics; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen / Streptococcus agalactiae / Streptokinase / Bacterial Proteins / Metalloendopeptidases / Fibrinolysin / Fibrinolysis Limits: Humans Language: En Journal: J Biol Chem Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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