Adenocarcinoma/genetics; Antineoplastic Agents/pharmacology; Biomarkers, Tumor/genetics; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Squamous Cell/genetics; Glutamates/pharmacology; Guanine/analogs & derivatives; Lung Neoplasms/genetics; Acute-Phase Proteins/antagonists & inhibitors; Acute-Phase Proteins/genetics; Acute-Phase Proteins/metabolism; Adenocarcinoma/drug therapy; Adenocarcinoma/pathology; Biomarkers, Tumor/metabolism; Blotting, Western; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Non-Small-Cell Lung/pathology; Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/pathology; Cell Cycle/drug effects; Cell Proliferation/drug effects; Cells, Cultured; Gene Expression Profiling; Guanine/pharmacology; Humans; Lipocalin-2; Lipocalins/antagonists & inhibitors; Lipocalins/genetics; Lipocalins/metabolism; Lung/drug effects; Lung/metabolism; Lung/pathology; Lung Neoplasms/drug therapy; Lung Neoplasms/pathology; NM23 Nucleoside Diphosphate Kinases/antagonists & inhibitors; NM23 Nucleoside Diphosphate Kinases/genetics; NM23 Nucleoside Diphosphate Kinases/metabolism; Oligonucleotide Array Sequence Analysis; Pemetrexed; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; RNA, Messenger/genetics; RNA, Small Interfering/pharmacology; Reverse Transcriptase Polymerase Chain Reaction