Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain.

Martins, I; Costa-Araújo, S; Fadel, J; Wilson, S P; Lima, D; Tavares, I

Martins, I; Costa-Araújo, S; Fadel, J; Wilson, S P; Lima, D; Tavares, I.

Affiliation

Martins I; Instituto de Histologia & Embriologia, Faculdade de Medicina, Universidade do Porto, Portugal Laboratório de Biologia Celular & Molecular, Faculdade de Medicina, Universidade do Porto, Portugal IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal Department of Physiology, Pharmacology and Neurosciences, University of South Carolina, USA.

Pain ; 151(1): 137-145, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20637543

Subject(s)

Neuralgia/therapy; Norepinephrine/metabolism; Reticular Formation/physiology; Adrenergic alpha-1 Receptor Agonists/pharmacology; Animals; Disease Models, Animal; Dopamine/metabolism; Dose-Response Relationship, Drug; Gene Transfer Techniques; Genetic Vectors/physiology; Green Fluorescent Proteins/genetics; Herpesvirus 1, Human/physiology; Humans; Hyperalgesia/drug therapy; Hyperalgesia/physiopathology; Male; Microdialysis; Neuralgia/metabolism; Norepinephrine/genetics; Pain Threshold/drug effects; Pain Threshold/physiology; Phenylephrine/pharmacology; Rats; Rats, Wistar; Reticular Formation/drug effects; Time Factors; Tyrosine 3-Monooxygenase/genetics; Tyrosine 3-Monooxygenase/metabolism; beta-Galactosidase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reticular Formation / Norepinephrine / Neuralgia Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Pain Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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