[Participation of endotoxin from gram-negative bacteria in mechanisms of regulation of thyroid status].

Alteration of thyroid hormone blood levels in rats in different periods after exposure of high dose of lipopolysaccharide from E. coli were studied. Direct inhibition of thyroid function without hypothalamus-pituitary dysfunction is revealed. High dose by high doses of bacterial endotoxin leads to changes in rat thyroid status caused by both hypothalamus-pituitary and thyroid hypofunction.