Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.

Wang, Jian-Bin; Erickson, Jon W; Fuji, Reina; Ramachandran, Sekar; Gao, Ping; Dinavahi, Ramani; Wilson, Kristin F; Ambrosio, Andre L B; Dias, Sandra M G; Dang, Chi V; Cerione, Richard A

Wang, Jian-Bin; Erickson, Jon W; Fuji, Reina; Ramachandran, Sekar; Gao, Ping; Dinavahi, Ramani; Wilson, Kristin F; Ambrosio, Andre L B; Dias, Sandra M G; Dang, Chi V; Cerione, Richard A.

Affiliation

Wang JB; Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.

Cancer Cell ; 18(3): 207-19, 2010 Sep 14.

Article in En | MEDLINE | ID: mdl-20832749

Subject(s)

Cell Transformation, Neoplastic/drug effects; Enzyme Inhibitors/pharmacology; Glutaminase/antagonists & inhibitors; Mitochondria/enzymology; rho GTP-Binding Proteins/antagonists & inhibitors; Animals; Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Female; Fibroblasts/drug effects; Fibroblasts/enzymology; Fibroblasts/pathology; Glutaminase/metabolism; Humans; Mice; Mitochondria/drug effects; NIH 3T3 Cells; Signal Transduction/drug effects; Transfection; rho GTP-Binding Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Transformation, Neoplastic / Rho GTP-Binding Proteins / Enzyme Inhibitors / Glutaminase / Mitochondria Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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