Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density.

Zhang, Can; Browne, Andrew; Divito, Jason R; Stevenson, Jesse A; Romano, Donna; Dong, Yuanlin; Xie, Zhongcong; Tanzi, Rudolph E

Zhang, Can; Browne, Andrew; Divito, Jason R; Stevenson, Jesse A; Romano, Donna; Dong, Yuanlin; Xie, Zhongcong; Tanzi, Rudolph E.

Affiliation

Zhang C; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

J Alzheimers Dis ; 22(2): 683-984, 2010.

Article in En | MEDLINE | ID: mdl-20847415

Subject(s)

Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/metabolism; Cell Count; Peptide Fragments/metabolism; Protein Processing, Post-Translational; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Protein Precursor/drug effects; Amyloid beta-Protein Precursor/genetics; Animals; Cell Count/methods; Cells, Cultured; Cerebral Cortex/cytology; Cricetinae; Cricetulus; Enzyme-Linked Immunosorbent Assay/methods; Humans; Mice; Molecular Weight; Neurons/metabolism; Protein Structure, Tertiary

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Cell Count / Protein Processing, Post-Translational / Amyloid beta-Peptides / Amyloid beta-Protein Precursor Limits: Animals / Humans Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2010 Document type: Article Affiliation country: United States Country of publication: Netherlands

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