Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.

Weiss, Eric R; Popova, Elena; Yamanaka, Hikaru; Kim, Hyung Cheol; Huibregtse, Jon M; Göttlinger, Heinrich

Weiss, Eric R; Popova, Elena; Yamanaka, Hikaru; Kim, Hyung Cheol; Huibregtse, Jon M; Göttlinger, Heinrich.

Affiliation

Weiss ER; Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

PLoS Pathog ; 6(9): e1001107, 2010 Sep 16.

Article in En | MEDLINE | ID: mdl-20862313

Subject(s)

Endosomal Sorting Complexes Required for Transport/metabolism; HIV Infections/virology; HIV-1/physiology; Ubiquitin-Protein Ligases/metabolism; Ubiquitin/metabolism; Virus Release/physiology; gag Gene Products, Human Immunodeficiency Virus/metabolism; Endosomal Sorting Complexes Required for Transport/antagonists & inhibitors; Endosomal Sorting Complexes Required for Transport/genetics; HIV Infections/genetics; HIV Infections/metabolism; Humans; Nedd4 Ubiquitin Protein Ligases; Protein Structure, Tertiary; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Ubiquitin-Protein Ligases/antagonists & inhibitors; Ubiquitin-Protein Ligases/genetics; Ubiquitination; Virus Replication; gag Gene Products, Human Immunodeficiency Virus/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Ubiquitin / Ubiquitin-Protein Ligases / Gag Gene Products, Human Immunodeficiency Virus / Endosomal Sorting Complexes Required for Transport / Virus Release Limits: Humans Language: En Journal: PLoS Pathog Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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