Systemic administration of ribbon-type decoy oligodeoxynucleotide against nuclear factor &#954;B and ets prevents abdominal aortic aneurysm in rat model.

Miyake, Takashi; Aoki, Motokuni; Osako, Mariana K; Shimamura, Munehisa; Nakagami, Hironori; Morishita, Ryuichi

Systemic administration of ribbon-type decoy oligodeoxynucleotide against nuclear factor κB and ets prevents abdominal aortic aneurysm in rat model.

Miyake, Takashi; Aoki, Motokuni; Osako, Mariana K; Shimamura, Munehisa; Nakagami, Hironori; Morishita, Ryuichi.

Affiliation

Miyake T; Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Mol Ther ; 19(1): 181-7, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20877343

Subject(s)

Aortic Aneurysm, Abdominal/prevention & control; NF-kappa B/antagonists & inhibitors; Oligodeoxyribonucleotides/administration & dosage; Oligodeoxyribonucleotides/chemistry; Proto-Oncogene Proteins c-ets/antagonists & inhibitors; Animals; Aortic Aneurysm, Abdominal/chemically induced; Aortic Aneurysm, Abdominal/genetics; Cathepsin B/antagonists & inhibitors; Cathepsin K/antagonists & inhibitors; Endonucleases/metabolism; Macrophages/drug effects; Macrophages/metabolism; Male; Matrix Metalloproteinases/metabolism; Models, Animal; Molecular Targeted Therapy/methods; NF-kappa B/genetics; NF-kappa B/metabolism; Oligodeoxyribonucleotides/genetics; Pancreatic Elastase/metabolism; Proto-Oncogene Proteins c-ets/genetics; Proto-Oncogene Proteins c-ets/metabolism; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodeoxyribonucleotides / NF-kappa B / Aortic Aneurysm, Abdominal / Proto-Oncogene Proteins c-ets Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2011 Document type: Article Affiliation country: Japan

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