Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT.

Hevir, Neli; Sinkovec, Jasna; Rizner, Tea Lanisnik

Hevir, Neli; Sinkovec, Jasna; Rizner, Tea Lanisnik.

Affiliation

Hevir N; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Mol Cell Endocrinol ; 331(1): 158-67, 2011 Jan 01.

Article in En | MEDLINE | ID: mdl-20887769

Subject(s)

Aryl Hydrocarbon Hydroxylases/genetics; Catechol O-Methyltransferase/genetics; Endometrial Neoplasms/enzymology; Endometrial Neoplasms/genetics; Estrogens/metabolism; Metabolic Detoxication, Phase II/genetics; Metabolic Detoxication, Phase I/genetics; Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP1B1; Down-Regulation; Endometrial Neoplasms/pathology; Endometrium/enzymology; Endometrium/pathology; Estradiol/biosynthesis; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase/genetics; Glucuronosyltransferase/metabolism; Glutathione S-Transferase pi/genetics; Glutathione S-Transferase pi/metabolism; Humans; Hydroxylation; Isoenzymes/genetics; Isoenzymes/metabolism; Middle Aged; Sulfotransferases/genetics; Sulfotransferases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Catechol O-Methyltransferase / Endometrial Neoplasms / Estrogens / Metabolic Detoxication, Phase I / Metabolic Detoxication, Phase II Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Mol Cell Endocrinol Year: 2011 Document type: Article Affiliation country: Slovenia Country of publication: Ireland

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