Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.

Huang, Steven K; Fisher, Aaron S; Scruggs, Anne M; White, Eric S; Hogaboam, Cory M; Richardson, Bruce C; Peters-Golden, Marc

Huang, Steven K; Fisher, Aaron S; Scruggs, Anne M; White, Eric S; Hogaboam, Cory M; Richardson, Bruce C; Peters-Golden, Marc.

Affiliation

Huang SK; Department of Internal Medicine, University of Michigan Medical School, 6301 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. stehuang@umich.edu

Am J Pathol ; 177(5): 2245-55, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20889571

Subject(s)

Dinoprostone/pharmacology; Fibroblasts/metabolism; Fibroblasts/pathology; Receptors, Prostaglandin E, EP2 Subtype/metabolism; Animals; Cells, Cultured; DNA Methylation; DNA Modification Methylases/genetics; DNA Modification Methylases/metabolism; Fibroblasts/cytology; Fibrosis/pathology; Humans; Mice; Mice, Inbred C57BL; PTEN Phosphohydrolase/metabolism; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptors, Prostaglandin E, EP2 Subtype/genetics; Signal Transduction/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dinoprostone / Receptors, Prostaglandin E, EP2 Subtype / Fibroblasts Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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