How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.

Wullschleger, Stephan; Sakamoto, Kei; Johnstone, Lana; Duce, Suzanne; Fleming, Stewart; Alessi, Dario R

Wullschleger, Stephan; Sakamoto, Kei; Johnstone, Lana; Duce, Suzanne; Fleming, Stewart; Alessi, Dario R.

Affiliation

Wullschleger S; MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Dis Model Mech ; 4(1): 95-103, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20959631

Subject(s)

Insulin Resistance; Neoplasms/enzymology; Neoplasms/pathology; Precancerous Conditions/enzymology; Precancerous Conditions/pathology; Proto-Oncogene Proteins c-akt/chemistry; Proto-Oncogene Proteins c-akt/metabolism; Animals; Cell Proliferation/drug effects; Enzyme Activation/drug effects; Humans; Insulin/pharmacology; Mice; Mutation/genetics; PTEN Phosphohydrolase/metabolism; Phosphorylation/drug effects; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Secondary; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precancerous Conditions / Insulin Resistance / Proto-Oncogene Proteins c-akt / Neoplasms Limits: Animals / Humans Language: En Journal: Dis Model Mech Journal subject: MEDICINA Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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