A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.

Saba, Laura M; Bennett, Beth; Hoffman, Paula L; Barcomb, Kelsey; Ishii, Takao; Kechris, Katerina; Tabakoff, Boris

Saba, Laura M; Bennett, Beth; Hoffman, Paula L; Barcomb, Kelsey; Ishii, Takao; Kechris, Katerina; Tabakoff, Boris.

Affiliation

Saba LM; Department of Pharmacology, University of Colorado Denver School of Medicine, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA.

Neuropharmacology ; 60(7-8): 1269-80, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21185315

Subject(s)

Alcohol Drinking/genetics; Central Nervous System Depressants/pharmacology; Ethanol/pharmacology; Synaptic Transmission/drug effects; Alcohol Drinking/metabolism; Alcohol Drinking/physiopathology; Animals; Brain/physiology; GTP-Binding Protein beta Subunits/genetics; GTP-Binding Protein beta Subunits/metabolism; Gene Expression/drug effects; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs/metabolism; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Quantitative Trait, Heritable; Rats; Receptors, GABA/physiology; gamma-Aminobutyric Acid/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Drinking / Central Nervous System Depressants / Synaptic Transmission / Ethanol Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Neuropharmacology Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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