Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord.

Morgado, C; Pereira-Terra, P; Cruz, C D; Tavares, I

Morgado, C; Pereira-Terra, P; Cruz, C D; Tavares, I.

Affiliation

Morgado C; Faculty of Medicine of Porto and IBMC, Institute of Histology and Embryology, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal.

Diabetes Obes Metab ; 13(2): 150-9, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21199267

Subject(s)

Diabetic Neuropathies/metabolism; Hyperalgesia/metabolism; Microglia/drug effects; Minocycline/administration & dosage; Potassium Chloride/metabolism; Spinal Cord/metabolism; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies/diet therapy; Diabetic Neuropathies/physiopathology; Hyperalgesia/drug therapy; Hyperalgesia/physiopathology; Male; Minocycline/pharmacology; Rats; Rats, Wistar; Spinal Cord/drug effects; Spinal Cord/physiopathology; Symporters; Synaptic Transmission/physiology; Up-Regulation/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium Chloride / Spinal Cord / Microglia / Diabetic Neuropathies / Hyperalgesia / Minocycline Limits: Animals Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2011 Document type: Article Affiliation country: Portugal Country of publication: United kingdom

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