Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.

Grimm, Marcus O W; Kuchenbecker, Johanna; Rothhaar, Tatjana L; Grösgen, Sven; Hundsdörfer, Benjamin; Burg, Verena K; Friess, Petra; Müller, Ulrike; Grimm, Heike S; Riemenschneider, Mathias; Hartmann, Tobias

Grimm, Marcus O W; Kuchenbecker, Johanna; Rothhaar, Tatjana L; Grösgen, Sven; Hundsdörfer, Benjamin; Burg, Verena K; Friess, Petra; Müller, Ulrike; Grimm, Heike S; Riemenschneider, Mathias; Hartmann, Tobias.

Affiliation

Grimm MO; Neurodegeneration and Neurobiology, Deutsches Institut für DemenzPrävention (DIDP), Homburg, Germany. marcus.grimm@uks.eu

J Neurochem ; 116(5): 916-25, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21214572

Subject(s)

Alkyl and Aryl Transferases/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Protein Precursor/metabolism; Brain/pathology; Plasmalogens/metabolism; Alkyl and Aryl Transferases/genetics; Alzheimer Disease/pathology; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/deficiency; Amyloid beta-Protein Precursor/genetics; Animals; Brain/metabolism; Cell Line; Cytidine Deaminase/genetics; Cytidine Deaminase/metabolism; Female; Fibroblasts; Gene Expression Regulation/genetics; Humans; Male; Mice; Mice, Knockout; Mutation/genetics; Neuroblastoma; Oxidative Stress/genetics; Oxidative Stress/physiology; Reactive Oxygen Species/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Plasmalogens / Amyloid beta-Protein Precursor / Alkyl and Aryl Transferases / Alzheimer Disease Limits: Animals / Female / Humans / Male Language: En Journal: J Neurochem Year: 2011 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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