A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis.

Lombard, Murielle; Salard, Isabelle; Sari, Marie-Agnès; Mansuy, Daniel; Buisson, Didier

Lombard, Murielle; Salard, Isabelle; Sari, Marie-Agnès; Mansuy, Daniel; Buisson, Didier.

Affiliation

Lombard M; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Université Paris Descartes, 45 rue des Saints-Pères, 75 270 Paris Cedex 06, France. murielle.lombard@parisdescartes.fr

Arch Biochem Biophys ; 508(1): 54-63, 2011 Apr 01.

Article in En | MEDLINE | ID: mdl-21241658

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Streptomyces/metabolism; Terfenadine/metabolism; Amino Acid Sequence; Cytochrome P-450 Enzyme System/chemistry; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/isolation & purification; Hydroxylation; Intracellular Space/enzymology; Intracellular Space/metabolism; Molecular Sequence Data; Oxidation-Reduction; Sequence Analysis, DNA; Stereoisomerism; Streptomyces/cytology; Streptomyces/enzymology; Substrate Specificity; Terfenadine/chemistry; Xenobiotics/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Terfenadine / Cytochrome P-450 Enzyme System Type of study: Prognostic_studies Language: En Journal: Arch Biochem Biophys Year: 2011 Document type: Article Affiliation country: France Country of publication: United States

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