Induction of rat UDP-glucuronosyltransferase and glutathione S-transferase activities by L-buthionine-S,R-sulfoximine without induction of cytochrome P-450.

Manning, B W; Franklin, M R

Manning, B W; Franklin, M R.

Affiliation

Manning BW; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112.

Toxicology ; 65(1-2): 149-59, 1990 Dec 17.

Article in En | MEDLINE | ID: mdl-2125759

Subject(s)

Antimetabolites/toxicity; Cytochrome P-450 Enzyme System/biosynthesis; Glucuronosyltransferase/biosynthesis; Glutathione Transferase/biosynthesis; Methionine Sulfoximine/analogs & derivatives; Animals; Buthionine Sulfoximine; Enzyme Induction; Glucuronosyltransferase/metabolism; Glutathione/analysis; Glutathione Transferase/metabolism; Male; Methionine Sulfoximine/toxicity; Microsomes, Liver/chemistry; Microsomes, Liver/enzymology; Rats; Rats, Inbred Strains

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Collection: 01-internacional Database: MEDLINE Main subject: Glucuronosyltransferase / Cytochrome P-450 Enzyme System / Glutathione Transferase / Methionine Sulfoximine / Antimetabolites Limits: Animals Language: En Journal: Toxicology Year: 1990 Document type: Article

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