Sitagliptin manufacture: a compelling tale of green chemistry, process intensification, and industrial asymmetric catalysis.

Desai, Aman A

Desai, Aman A.

Affiliation

Desai AA; Process Chemistry and Development, Core R & D, The Dow Chemical Company, Midland, MI 48674, USA. AADesai@dow.com

Angew Chem Int Ed Engl ; 50(9): 1974-6, 2011 Feb 25.

Article in En | MEDLINE | ID: mdl-21284073

Subject(s)

Pyrazines/chemistry; Triazoles/chemistry; Biocatalysis; Diabetes Mellitus, Type 2/drug therapy; Green Chemistry Technology; Humans; Pyrazines/chemical synthesis; Pyrazines/therapeutic use; Ruthenium/chemistry; Sitagliptin Phosphate; Transaminases/metabolism; Triazoles/chemical synthesis; Triazoles/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Triazoles Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2011 Document type: Article Affiliation country: United States Country of publication: Germany

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