The TSP motif in AP180 inhibits phospholipase D1 activity resulting in increased efficacy of anticancer drug via its direct binding to carboxyl terminal of phospholipase D1.

Cho, Ju Hwan; Oh, Doo-Yi; Kim, Hyoung-Ju; Park, Shin-Young; Choi, Hye-Jin; Kwon, Sung-Joon; Lee, Ki-Sung; Han, Joong-Soo

Cho, Ju Hwan; Oh, Doo-Yi; Kim, Hyoung-Ju; Park, Shin-Young; Choi, Hye-Jin; Kwon, Sung-Joon; Lee, Ki-Sung; Han, Joong-Soo.

Affiliation

Cho JH; Biomedical Research Institute and Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of Korea.

Cancer Lett ; 302(2): 144-54, 2011 Mar 28.

Article in En | MEDLINE | ID: mdl-21296491

Subject(s)

Antineoplastic Agents/pharmacology; Monomeric Clathrin Assembly Proteins/metabolism; Phospholipase D/metabolism; Stomach Neoplasms/enzymology; Amino Acid Motifs; Cell Line, Tumor; Cell Survival/drug effects; Humans; Monomeric Clathrin Assembly Proteins/genetics; Protein Binding/drug effects; Sequence Deletion

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phospholipase D / Stomach Neoplasms / Monomeric Clathrin Assembly Proteins / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Lett Year: 2011 Document type: Article

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