Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells.

Mise, Josko; Dembitz, Vilma; Banfic, Hrvoje; Visnjic, Dora

Mise, Josko; Dembitz, Vilma; Banfic, Hrvoje; Visnjic, Dora.

Affiliation

Mise J; Department of Physiology, University of Zagreb, Zagreb, Croatia.

Pathol Oncol Res ; 17(3): 645-56, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21336564

Subject(s)

Cell Differentiation; Cell Proliferation; Phosphoinositide-3 Kinase Inhibitors; TOR Serine-Threonine Kinases/antagonists & inhibitors; Blotting, Western; Cell Cycle; Drug Synergism; Extracellular Signal-Regulated MAP Kinases/metabolism; Humans; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Sirolimus/pharmacology; TOR Serine-Threonine Kinases/metabolism; Tretinoin/pharmacology; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Cell Proliferation / TOR Serine-Threonine Kinases / Phosphoinositide-3 Kinase Inhibitors Limits: Humans Language: En Journal: Pathol Oncol Res Journal subject: NEOPLASIAS / PATOLOGIA Year: 2011 Document type: Article Affiliation country: Croatia Country of publication: Switzerland

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