Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation.

He, X; Smeets, R L; Koenen, H J P M; Vink, P M; Wagenaars, J; Boots, A M H; Joosten, I

He, X; Smeets, R L; Koenen, H J P M; Vink, P M; Wagenaars, J; Boots, A M H; Joosten, I.

Affiliation

He X; Department of Laboratory Medicine, Laboratory Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Am J Transplant ; 11(3): 439-49, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21342445

Subject(s)

Antibiotics, Antineoplastic/pharmacology; CD27 Ligand/metabolism; CD4-Positive T-Lymphocytes/drug effects; Cell Proliferation/drug effects; Guanine Nucleotides/metabolism; Mycophenolic Acid/pharmacology; Signal Transduction/drug effects; Apoptosis/drug effects; Blotting, Western; CD28 Antigens/metabolism; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Cells, Cultured; Flow Cytometry; Humans; IMP Dehydrogenase/metabolism; Interferon-gamma/metabolism; Interleukin-17/metabolism; Interleukin-2/metabolism; Signal Transduction/immunology; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Signal Transduction / Cell Proliferation / CD27 Ligand / Guanine Nucleotides / Antibiotics, Antineoplastic / Mycophenolic Acid Type of study: Guideline Limits: Humans Language: En Journal: Am J Transplant Journal subject: TRANSPLANTE Year: 2011 Document type: Article Affiliation country: Netherlands Country of publication: United States

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