Inhibition of keratin 17 expression with antisense and RNAi strategies: exploring novel therapy for psoriasis.

Chang, Ting; Sun, Linchao; Wang, Yan; Wang, Datai; Li, Wei; Li, Chunying; Gao, Tianwen; Liu, Yufeng; Wang, Gang

Chang, Ting; Sun, Linchao; Wang, Yan; Wang, Datai; Li, Wei; Li, Chunying; Gao, Tianwen; Liu, Yufeng; Wang, Gang.

Affiliation

Chang T; Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Exp Dermatol ; 20(7): 555-60, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21355890

Subject(s)

Gene Expression/drug effects; Keratin-17/metabolism; Oligodeoxyribonucleotides, Antisense/therapeutic use; Psoriasis/drug therapy; RNA, Small Interfering/therapeutic use; Animals; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Line; Cell Proliferation/drug effects; Disease Models, Animal; Down-Regulation/genetics; Epidermis/metabolism; Epidermis/pathology; Humans; Keratin-17/antagonists & inhibitors; Keratin-17/genetics; Keratinocytes/drug effects; Keratinocytes/metabolism; Mice; Mice, SCID; Oligodeoxyribonucleotides, Antisense/administration & dosage; Oligodeoxyribonucleotides, Antisense/pharmacology; Psoriasis/metabolism; Psoriasis/pathology; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/pharmacology; Skin/metabolism; Skin/pathology; Skin Transplantation; Transfection; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Gene Expression / Oligodeoxyribonucleotides, Antisense / RNA, Small Interfering / Keratin-17 Limits: Animals / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2011 Document type: Article Affiliation country: China Country of publication: Denmark

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