Early gestational gene transfer of IL-10 by systemic administration of lentiviral vector can prevent arthritis in a murine model.

Roybal, J L; Endo, M; Radu, A; Zoltick, P W; Flake, A W

Roybal, J L; Endo, M; Radu, A; Zoltick, P W; Flake, A W.

Affiliation

Roybal JL; Department of Surgery, The Children's Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

Gene Ther ; 18(7): 719-26, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21390071

Subject(s)

Arthritis, Experimental/prevention & control; Arthritis, Rheumatoid/prevention & control; Fetal Heart; Gene Transfer Techniques; Genetic Vectors; Interleukin-10/genetics; Lentivirus/genetics; Animals; Arthritis, Experimental/genetics; Arthritis, Rheumatoid/genetics; Cartilage/metabolism; Genetic Therapy; Green Fluorescent Proteins/genetics; Interleukin-10/blood; Mice; Synovial Membrane/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Interleukin-10 / Gene Transfer Techniques / Lentivirus / Fetal Heart / Genetic Vectors Type of study: Prognostic_studies Limits: Animals Language: En Journal: Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2011 Document type: Article Affiliation country: United States

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