Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor.

Gardès, Christophe; Blum, Denise; Bleicher, Konrad; Chaput, Evelyne; Ebeling, Martin; Hartman, Peter; Handschin, Corinne; Richter, Hans; Benson, G Martin

Gardès, Christophe; Blum, Denise; Bleicher, Konrad; Chaput, Evelyne; Ebeling, Martin; Hartman, Peter; Handschin, Corinne; Richter, Hans; Benson, G Martin.

Affiliation

Gardès C; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland. Electronic address: christophe.gardes@roche.com.
Blum D; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Bleicher K; Chemistry, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Chaput E; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Ebeling M; Bio-informatics, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Hartman P; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Handschin C; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Richter H; Chemistry, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.
Benson GM; Departments of Metabolic Diseases, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.

J Lipid Res ; 52(6): 1188-1199, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21464203

Subject(s)

Apolipoprotein A-I; Gene Expression Regulation/drug effects; Liver/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Taurocholic Acid/pharmacology; Animals; Apolipoprotein A-I/genetics; Apolipoprotein A-I/metabolism; Binding Sites; Conserved Sequence; Cricetinae; Female; Humans; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Promoter Regions, Genetic/drug effects; Protein Binding; RNA, Messenger/analysis; RNA, Messenger/biosynthesis; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear/genetics; Scintillation Counting; Species Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taurocholic Acid / Gene Expression Regulation / Apolipoprotein A-I / Receptors, Cytoplasmic and Nuclear / Liver Limits: Animals / Female / Humans / Male Language: En Journal: J Lipid Res Year: 2011 Document type: Article

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