Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study.

van Asseldonk, Edwin J P; Stienstra, Rinke; Koenen, Tim B; Joosten, Leo A B; Netea, Mihai G; Tack, Cees J

van Asseldonk, Edwin J P; Stienstra, Rinke; Koenen, Tim B; Joosten, Leo A B; Netea, Mihai G; Tack, Cees J.

Affiliation

van Asseldonk EJ; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands. e.vanasseldonk@aig.umcn.nl

J Clin Endocrinol Metab ; 96(7): 2119-26, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21508140

Subject(s)

Blood Glucose/metabolism; Hypoglycemic Agents/therapeutic use; Insulin Resistance/physiology; Interleukin 1 Receptor Antagonist Protein/therapeutic use; Metabolic Syndrome/drug therapy; Adipose Tissue/drug effects; Adipose Tissue/metabolism; Adipose Tissue/physiopathology; C-Reactive Protein/metabolism; Cross-Over Studies; Double-Blind Method; Female; Glucose Clamp Technique; Humans; Hypoglycemic Agents/pharmacology; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Interleukin 1 Receptor Antagonist Protein/pharmacology; Male; Metabolic Syndrome/metabolism; Metabolic Syndrome/physiopathology; Middle Aged; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Glucose / Insulin Resistance / Metabolic Syndrome / Interleukin 1 Receptor Antagonist Protein / Hypoglycemic Agents Type of study: Clinical_trials / Diagnostic_studies Limits: Female / Humans / Male / Middle aged Language: En Journal: J Clin Endocrinol Metab Year: 2011 Document type: Article Affiliation country: Netherlands

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