Low expression of AcrB in the deoxycholate-sensitive strains of Salmonella enterica subspecies enterica serovar Pullorum.
Microbiol Immunol
; 55(5): 366-8, 2011 May.
Article
in En
| MEDLINE
| ID: mdl-21517946
We investigated the mechanism responsible for bile susceptibility in three deoxycholate-sensitive (DCs) strains of Salmonella enterica subspecies enterica serovar Pullorum isolated in 1958 in Japan. Of the genes encoding the AcrAB-TolC efflux system, the expression of acrB mRNA was 10-fold lower in the DCs strains than in a deoxycholate-resistant (DCr) strain, whereas those of the acrA and tolC genes were two-fold lower. These results suggested that low expression of acrB was strongly correlated with bile susceptibility in the DCs strains. In addition, the increase in tolC expression levels was not detected in the DCr mutants derived from the DCs strains, suggesting that difference in the expression levels of tolC is not associated with bile susceptibility.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Bacterial Proteins
/
Down-Regulation
/
Salmonella enterica
/
Deoxycholic Acid
Type of study:
Diagnostic_studies
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
Microbiol Immunol
Year:
2011
Document type:
Article
Affiliation country:
Japan
Country of publication:
Australia