Extracellular Matrix/metabolism; Fibroblasts/metabolism; Gene Expression/drug effects; Proto-Oncogenes/genetics; Transforming Growth Factors/pharmacology; Adenosine Diphosphate/metabolism; Animals; Cell Transformation, Neoplastic/drug effects; Cell Transformation, Neoplastic/pathology; Cells, Cultured; Collagen/genetics; Collagen/metabolism; Extracellular Matrix/physiology; Extracellular Matrix/ultrastructure; Fibroblasts/physiology; Fibroblasts/ultrastructure; Fibronectins/genetics; Fibronectins/metabolism; Integrins/genetics; Integrins/metabolism; Pertussis Toxin; Platelet-Derived Growth Factor/genetics; Platelet-Derived Growth Factor/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-sis; Receptors, Cell Surface/metabolism; Receptors, Transforming Growth Factor beta; Transforming Growth Factors/metabolism; Virulence Factors, Bordetella/pharmacology