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Antigen-presenting cell (APC) subsets in ovarian cancer.
Wilke, Cailin Moira; Kryczek, Ilona; Zou, Weiping.
Affiliation
  • Wilke CM; Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan 48109-0669, USA.
Int Rev Immunol ; 30(2-3): 120-6, 2011.
Article in En | MEDLINE | ID: mdl-21557638
The major human antigen-presenting cells (APCs) include monocytes/macrophages, myeloid dendritic cells (mDC), plasmacytoid dendritic cells (pDC), and B cells. These APC subsets have been observed in ovarian tumor environments. Their phenotypes and functionalities are subjected to alteration by multiple factors in the tumor environment. In this review, we summarize the nature, cellular interactions, and prognostic significance of the main APC populations in ovarian cancer, and discuss the relevance of manipulating APC subsets for patient treatment.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Immunotherapy / Antigen-Presenting Cells Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Int Rev Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Immunotherapy / Antigen-Presenting Cells Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Int Rev Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom