The in vitro hepatic microsomal metabolism of benzoic acid benzylidenehydrazide.
Drug Metabol Drug Interact
; 13(4): 285-94, 1997.
Article
in En
| MEDLINE
| ID: mdl-21568806
ABSTRACT
The in vitro hepatic microsomal metabolism of benzoic acid benzylidenehydrazide was studied using rat microsomal preparations fortified with NADPH. The substrate and its potential metabolites were synthesised and their structures were elucidated by use of their UV, IR, ¹H-NMR and mass spectral characteristics. The results showed this compound produced hydrolytic metabolites, i.e. benzoic hydrazide and benzaldehyde, together with a phenolic metabolite, benzoic acid phydroxybenzylidene hydrazide.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schiff Bases
/
Benzamides
/
Microsomes, Liver
/
Hydrazines
Limits:
Animals
Language:
En
Journal:
Drug Metabol Drug Interact
Journal subject:
FARMACOLOGIA
Year:
1997
Document type:
Article