Comparison of metabolic soft spot predictions of CYP3A4, CYP2C9 and CYP2D6 substrates using MetaSite and StarDrop.

Shin, Young G; Le, Hoa; Khojasteh, Cyrus; Hop, Cornelis E C A

Shin, Young G; Le, Hoa; Khojasteh, Cyrus; Hop, Cornelis E C A.

Affiliation

Shin YG; Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA way, MS 412a, South San Francisco, CA 94080, USA. yshin@gene.com

Comb Chem High Throughput Screen ; 14(9): 811-23, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21605066

Subject(s)

Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP3A/metabolism; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Humans; Microsomes, Liver/enzymology; Spectrophotometry, Ultraviolet; Substrate Specificity; Tandem Mass Spectrometry

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Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 CYP2D6 / Cytochrome P-450 CYP3A Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Comb Chem High Throughput Screen Journal subject: BIOLOGIA MOLECULAR / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United Arab Emirates

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