Cytotoxic 1,2-dialkynylimidazole-based aza-enediynes: aza-Bergman rearrangement rates do not predict cytotoxicity.

Laroche, Christophe; Li, Jing; Kerwin, Sean M

Laroche, Christophe; Li, Jing; Kerwin, Sean M.

Affiliation

Laroche C; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Texas 78712, USA.

J Med Chem ; 54(14): 5059-69, 2011 Jul 28.

Article in En | MEDLINE | ID: mdl-21667990

Subject(s)

Alkynes/chemical synthesis; Antineoplastic Agents/chemical synthesis; Imidazoles/chemical synthesis; Alkynes/chemistry; Alkynes/pharmacology; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Cattle; Cell Line, Tumor; Cyclization; DNA Cleavage; DNA, Superhelical/chemistry; Drug Screening Assays, Antitumor; Drug Stability; Hot Temperature; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; Kinetics; Serum Albumin, Bovine/chemistry; Stereoisomerism; Structure-Activity Relationship; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkynes / Imidazoles / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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