In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer.

Doherty, Leo F; Bromer, Jason G; Zhou, Yuping; Aldad, Tamir S; Taylor, Hugh S

Doherty, Leo F; Bromer, Jason G; Zhou, Yuping; Aldad, Tamir S; Taylor, Hugh S.

Affiliation

Doherty LF; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.

Horm Cancer ; 1(3): 146-55, 2010 Jun.

Article in En | MEDLINE | ID: mdl-21761357

Subject(s)

Diethylstilbestrol/toxicity; Endocrine Disruptors/toxicity; Histone-Lysine N-Methyltransferase/biosynthesis; Mammary Neoplasms, Experimental/metabolism; Phenols/toxicity; Prenatal Exposure Delayed Effects/chemically induced; Animals; Benzhydryl Compounds; Blotting, Western; Carcinogens/toxicity; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic/drug effects; Female; Gene Expression/drug effects; Humans; Mice; Polycomb Repressive Complex 2; Pregnancy; Prenatal Exposure Delayed Effects/metabolism; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Prenatal Exposure Delayed Effects / Histone-Lysine N-Methyltransferase / Diethylstilbestrol / Endocrine Disruptors / Mammary Neoplasms, Experimental Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Horm Cancer Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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