CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice.

Kaushal, Nidhi; Seminerio, Michael J; Shaikh, Jamaluddin; Medina, Mark A; Mesangeau, Christophe; Wilson, Lisa L; McCurdy, Christopher R; Matsumoto, Rae R

Kaushal, Nidhi; Seminerio, Michael J; Shaikh, Jamaluddin; Medina, Mark A; Mesangeau, Christophe; Wilson, Lisa L; McCurdy, Christopher R; Matsumoto, Rae R.

Affiliation

Kaushal N; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA.

Neuropharmacology ; 61(5-6): 992-1000, 2011.

Article in En | MEDLINE | ID: mdl-21762711

Subject(s)

Central Nervous System Stimulants/toxicity; Methamphetamine/toxicity; Neurotoxicity Syndromes/drug therapy; Neurotoxicity Syndromes/pathology; Piperazines/pharmacology; Protective Agents/pharmacology; Receptors, sigma/antagonists & inhibitors; Sulfur Compounds/pharmacology; Animals; Body Temperature/drug effects; Central Nervous System Stimulants/pharmacology; Cocaine/antagonists & inhibitors; Dopamine/analysis; Drug Evaluation, Preclinical; Fever/chemically induced; Fever/metabolism; Male; Methamphetamine/pharmacology; Mice; Molecular Targeted Therapy; Motor Activity/drug effects; Motor Activity/physiology; Neurotoxicity Syndromes/metabolism; Piperazines/therapeutic use; Protective Agents/therapeutic use; Receptors, sigma/metabolism; Serotonin/analysis; Serotonin Plasma Membrane Transport Proteins/analysis; Serotonin Plasma Membrane Transport Proteins/drug effects; Serotonin Plasma Membrane Transport Proteins/metabolism; Sulfur Compounds/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Sulfur Compounds / Receptors, sigma / Protective Agents / Neurotoxicity Syndromes / Central Nervous System Stimulants / Methamphetamine Limits: Animals Language: En Journal: Neuropharmacology Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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