[Evidence-based cardiology: practical applications from epidemiology. II. The use of biomarkers]. / Cardiología " basada en la evidencia": aplicaciones prácticas de la epidemiología. II. El uso de biomarcadores.

The use of biomarkers that show an association with the development of cardiovascular disease needs a careful evaluation in regard to the quality of evidence that establishes their relationship. Although observational studies have been paramount to establish the importance of the traditional risk factors, we can only screen and intervene on biomarkers when there is demonstrated benefit in well-designed randomized clinical trials.