Long-lasting immunoprotective and therapeutic effects of a hyperstable E7 oligomer based vaccine in a murine human papillomavirus tumor model.

Cerutti, María L; Alonso, Leonardo G; Tatti, Silvio; de Prat-Gay, Gonzalo

Cerutti, María L; Alonso, Leonardo G; Tatti, Silvio; de Prat-Gay, Gonzalo.

Affiliation

Cerutti ML; XBio SA, Concepción Arenal 4220, Ciudad de Buenos Aires, Argentina.

Int J Cancer ; 130(8): 1813-20, 2012 Apr 15.

Article in En | MEDLINE | ID: mdl-21780110

Subject(s)

Cancer Vaccines/immunology; Neoplasms/immunology; Papillomavirus E7 Proteins/immunology; Papillomavirus Infections/immunology; Papillomavirus Vaccines/immunology; Uterine Cervical Neoplasms/immunology; Adjuvants, Immunologic/administration & dosage; Animals; Cancer Vaccines/administration & dosage; Dose-Response Relationship, Drug; Female; Humans; Immunotherapy/methods; Kaplan-Meier Estimate; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neoplasms/therapy; Neoplasms/virology; Oligodeoxyribonucleotides/administration & dosage; Oligodeoxyribonucleotides/immunology; Papillomavirus E7 Proteins/chemistry; Papillomavirus E7 Proteins/ultrastructure; Papillomavirus Infections/chemically induced; Papillomavirus Infections/therapy; Papillomavirus Vaccines/administration & dosage; Protein Multimerization; Protein Stability; Treatment Outcome; Uterine Cervical Neoplasms/therapy; Uterine Cervical Neoplasms/virology; Vaccination/methods

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Cancer Vaccines / Papillomavirus Infections / Papillomavirus E7 Proteins / Papillomavirus Vaccines / Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Int J Cancer Year: 2012 Document type: Article Affiliation country: Argentina Country of publication: United States

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