Anti-inflammatory activity of Premna corymbosa (Burm.f.) Rottl. & Willd. leaves extracts in Wistar albino rats.
Asian Pac J Trop Med
; 4(7): 510-3, 2011 Jul.
Article
in En
| MEDLINE
| ID: mdl-21803299
OBJECTIVE: To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract (PCEE) at doses of 200 and 400 mg/kg body weight in acute and chronic models of inflammation in experimental animals. METHODS: In the acute toxicity study, a single dose of PCEE of 2 000 mg/kg body weight, p.o. was administered and observed for 48 h. In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. RESULTS: In acute models, egg albumin induced paw edema PCEE significantly (P<0.01) inhibited the edema formation. In chronic model, cotton pellet induced granuloma formation in rats PCEE significantly (P<0.01) reduced the granuloma formation with percentage inhibition of 35.17% and 50.38 % respectively. CONCLUSIONS: The present study establishes the antiinflammatory activity of Premna corymbosa leaves.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Extracts
/
Plant Leaves
/
Verbenaceae
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Asian Pac J Trop Med
Year:
2011
Document type:
Article
Affiliation country:
India
Country of publication:
India