Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

Toller, Isabella M; Neelsen, Kai J; Steger, Martin; Hartung, Mara L; Hottiger, Michael O; Stucki, Manuel; Kalali, Behnam; Gerhard, Markus; Sartori, Alessandro A; Lopes, Massimo; Müller, Anne

Toller, Isabella M; Neelsen, Kai J; Steger, Martin; Hartung, Mara L; Hottiger, Michael O; Stucki, Manuel; Kalali, Behnam; Gerhard, Markus; Sartori, Alessandro A; Lopes, Massimo; Müller, Anne.

Affiliation

Toller IM; Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, Switzerland.

Proc Natl Acad Sci U S A ; 108(36): 14944-9, 2011 Sep 06.

Article in En | MEDLINE | ID: mdl-21896770

Subject(s)

Bacterial Adhesion; DNA Breaks, Double-Stranded; Helicobacter Infections/metabolism; Helicobacter pylori/metabolism; Stomach Neoplasms/metabolism; Adaptor Proteins, Signal Transducing; Animals; Antigens, Bacterial/genetics; Antigens, Bacterial/metabolism; Ataxia Telangiectasia Mutated Proteins; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Chromosomal Proteins, Non-Histone/genetics; Chromosomal Proteins, Non-Histone/metabolism; Chromosome Aberrations; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Epithelial Cells/metabolism; Epithelial Cells/microbiology; Epithelial Cells/pathology; Genomic Islands; Helicobacter Infections/complications; Helicobacter Infections/pathology; Histones/genetics; Histones/metabolism; Humans; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Mice; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Phosphorylation; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Stomach Neoplasms/genetics; Stomach Neoplasms/microbiology; Stomach Neoplasms/pathology; Trans-Activators/genetics; Trans-Activators/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Tumor Suppressor p53-Binding Protein 1

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Bacterial Adhesion / Helicobacter pylori / Helicobacter Infections / DNA Breaks, Double-Stranded Type of study: Risk_factors_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2011 Document type: Article Affiliation country: Switzerland Country of publication: United States

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