Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.

Yang, Li-Ping; Zhou, Zhi-Wei; Chen, Xiao-Wu; Li, Chun Guang; Sneed, Kevin B; Liang, Jun; Zhou, Shu-Feng

Yang, Li-Ping; Zhou, Zhi-Wei; Chen, Xiao-Wu; Li, Chun Guang; Sneed, Kevin B; Liang, Jun; Zhou, Shu-Feng.

Affiliation

Yang LP; School of Health Sciences & Health Innovations Research Institute, RMIT University, Bundoora, Victoria, Australia.

Xenobiotica ; 42(3): 238-55, 2012 Mar.

Article in En | MEDLINE | ID: mdl-21970686

Subject(s)

Computer Simulation; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors/pharmacology; Models, Molecular; Plant Preparations/pharmacology; Amino Acid Sequence; Amino Acids/metabolism; Binding Sites; Biocatalysis/drug effects; Conserved Sequence; Crystallography, X-Ray; Cytochrome P-450 CYP1A2/chemistry; Drug Evaluation, Preclinical; Enzyme Inhibitors/chemistry; Heme/metabolism; Humans; Ligands; Molecular Sequence Data; Plant Preparations/chemistry; Protein Structure, Secondary; Reproducibility of Results; Substrate Specificity/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Models, Molecular / Plant Preparations / Enzyme Inhibitors / Cytochrome P-450 CYP1A2 Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Xenobiotica Year: 2012 Document type: Article Affiliation country: Australia

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