Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response.

Chanan-Khan, Asher A; Chitta, Kasyapa; Ersing, Noreen; Paulus, Aneel; Masood, Aisha; Sher, Taimur; Swaika, Abhisek; Wallace, Paul K; Mashtare, Terry L; Wilding, Greg; Lee, Kelvin; Czuczman, Myron S; Borrello, Ivan; Bangia, Naveen

Chanan-Khan, Asher A; Chitta, Kasyapa; Ersing, Noreen; Paulus, Aneel; Masood, Aisha; Sher, Taimur; Swaika, Abhisek; Wallace, Paul K; Mashtare, Terry L; Wilding, Greg; Lee, Kelvin; Czuczman, Myron S; Borrello, Ivan; Bangia, Naveen.

Affiliation

Chanan-Khan AA; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA. chanan-khan.asher@mayo.edu

Br J Haematol ; 155(4): 457-67, 2011 Nov.

Article in En | MEDLINE | ID: mdl-22010965

Subject(s)

Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/immunology; Thalidomide/analogs & derivatives; B7-1 Antigen/biosynthesis; B7-1 Antigen/immunology; B7-2 Antigen/biosynthesis; B7-2 Antigen/immunology; CD40 Ligand/biosynthesis; CD40 Ligand/immunology; Cytokines/blood; Cytokines/immunology; Humans; Immunophenotyping; Killer Cells, Natural/drug effects; Killer Cells, Natural/immunology; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell/blood; Lymphocyte Activation/drug effects; MAP Kinase Signaling System/drug effects; Thalidomide/therapeutic use; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thalidomide / Leukemia, Lymphocytic, Chronic, B-Cell Type of study: Prognostic_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2011 Document type: Article Affiliation country: United States

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