Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.

Francis, Heather L; Demorrow, Sharon; Franchitto, Antonio; Venter, Julie K; Mancinelli, Romina A; White, Mellanie A; Meng, Fanyin; Ueno, Yoshiyuki; Carpino, Guido; Renzi, Anastasia; Baker, Kimberly K; Shine, Hannah E; Francis, Taylor C; Gaudio, Eugenio; Alpini, Gianfranco D; Onori, Paolo

Francis, Heather L; Demorrow, Sharon; Franchitto, Antonio; Venter, Julie K; Mancinelli, Romina A; White, Mellanie A; Meng, Fanyin; Ueno, Yoshiyuki; Carpino, Guido; Renzi, Anastasia; Baker, Kimberly K; Shine, Hannah E; Francis, Taylor C; Gaudio, Eugenio; Alpini, Gianfranco D; Onori, Paolo.

Affiliation

Francis HL; Department of Internal Medicine, Scott and White Digestive Disease Research Center, Scott and White Hospital and Texas A&M Health Science Center, College of Medicine, Temple, TX, USA.

Lab Invest ; 92(2): 282-94, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22064319

Subject(s)

Bile Ducts/drug effects; Calcium/metabolism; Cell Proliferation/drug effects; Cyclic AMP/metabolism; Histamine/pharmacology; Inositol Phosphates/metabolism; Signal Transduction/drug effects; Animals; Bile Ducts/cytology; Bile Ducts/enzymology; Bile Ducts/metabolism; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases/metabolism; Male; Phosphorylation; Protein Kinase C-alpha/metabolism; Rats; Rats, Inbred F344

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Ducts / Signal Transduction / Histamine / Calcium / Cyclic AMP / Cell Proliferation / Inositol Phosphates Limits: Animals Language: En Journal: Lab Invest Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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