Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus.

Pechnick, Robert N; Zonis, Svetlana; Wawrowsky, Kolja; Cosgayon, Rosemarie; Farrokhi, Catherine; Lacayo, Liliana; Chesnokova, Vera

Pechnick, Robert N; Zonis, Svetlana; Wawrowsky, Kolja; Cosgayon, Rosemarie; Farrokhi, Catherine; Lacayo, Liliana; Chesnokova, Vera.

Affiliation

Pechnick RN; Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.

PLoS One ; 6(11): e27290, 2011.

Article in En | MEDLINE | ID: mdl-22076148

Subject(s)

Antidepressive Agents/pharmacology; Cyclin-Dependent Kinase Inhibitor p21/physiology; Hippocampus/cytology; Hippocampus/drug effects; Neurons/cytology; Neurons/drug effects; Stem Cells/drug effects; Animals; Blotting, Western; Cell Proliferation/drug effects; Cyclin-Dependent Kinase Inhibitor p21/antagonists & inhibitors; Depression/drug therapy; Female; Fluoxetine/pharmacology; Hippocampus/metabolism; Imipramine/pharmacology; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons/metabolism; RNA, Small Interfering/genetics; Selective Serotonin Reuptake Inhibitors/pharmacology; Swimming

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Cyclin-Dependent Kinase Inhibitor p21 / Hippocampus / Antidepressive Agents / Neurons Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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