Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Barrett, Robert; Zhang, Xiaolan; Koon, Hon Wai; Vu, Michelle; Chang, Jyh-Yau; Yeager, Nicole; Nguyen, Mary Ann; Michelsen, Kathrin S; Berel, Dror; Pothoulakis, Charalabos; Targan, Stephan R; Shih, David Q

Barrett, Robert; Zhang, Xiaolan; Koon, Hon Wai; Vu, Michelle; Chang, Jyh-Yau; Yeager, Nicole; Nguyen, Mary Ann; Michelsen, Kathrin S; Berel, Dror; Pothoulakis, Charalabos; Targan, Stephan R; Shih, David Q.

Affiliation

Barrett R; Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Am J Pathol ; 180(2): 636-49, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22138299

Subject(s)

Colitis/etiology; Colon/pathology; Intestinal Mucosa/metabolism; Tumor Necrosis Factor Ligand Superfamily Member 15/metabolism; Adoptive Transfer; Animals; Chronic Disease; Colitis/pathology; Colon/metabolism; Constriction, Pathologic/etiology; Fibrosis/etiology; Humans; Interleukin-17/metabolism; Lymphocyte Activation/physiology; Mice; Mice, Transgenic; Peroxidase/metabolism; T-Lymphocytes/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis / Colon / Tumor Necrosis Factor Ligand Superfamily Member 15 / Intestinal Mucosa Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Pathol Year: 2012 Document type: Article Country of publication: United States

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