Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.

Sharina, Iraida; Sobolevsky, Michael; Doursout, Marie-Francoise; Gryko, Dorota; Martin, Emil

Sharina, Iraida; Sobolevsky, Michael; Doursout, Marie-Francoise; Gryko, Dorota; Martin, Emil.

Affiliation

Sharina I; Department of Internal Medicine, Division of Cardiology, UT Health Science Center in Houston, Medical School, 1941 East Rd., Houston, TX 77054, USA.

J Pharmacol Exp Ther ; 340(3): 723-32, 2012 Mar.

Article in En | MEDLINE | ID: mdl-22171090

Subject(s)

Cobamides/pharmacology; Guanylate Cyclase/drug effects; Receptors, Cytoplasmic and Nuclear/drug effects; Animals; Catalytic Domain; Cell Line, Tumor; Humans; Male; Nitric Oxide/physiology; Pyrazoles/pharmacology; Pyridines/pharmacology; Rats; Rats, Sprague-Dawley; Soluble Guanylyl Cyclase; Structure-Activity Relationship; Vitamin B 12/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cobamides / Receptors, Cytoplasmic and Nuclear / Guanylate Cyclase Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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