The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.

Ponader, Sabine; Chen, Shih-Shih; Buggy, Joseph J; Balakrishnan, Kumudha; Gandhi, Varsha; Wierda, William G; Keating, Michael J; O'Brien, Susan; Chiorazzi, Nicholas; Burger, Jan A

Ponader, Sabine; Chen, Shih-Shih; Buggy, Joseph J; Balakrishnan, Kumudha; Gandhi, Varsha; Wierda, William G; Keating, Michael J; O'Brien, Susan; Chiorazzi, Nicholas; Burger, Jan A.

Affiliation

Ponader S; Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230, USA.

Blood ; 119(5): 1182-9, 2012 Feb 02.

Article in En | MEDLINE | ID: mdl-22180443

Subject(s)

Chemotaxis, Leukocyte/drug effects; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Leukemic Infiltration/prevention & control; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Adenine/analogs & derivatives; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Cell Survival/drug effects; Cells, Cultured; Humans; Leukemic Infiltration/pathology; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; Piperidines; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrazoles/therapeutic use; Pyrimidines/therapeutic use; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Leukemia, Lymphocytic, Chronic, B-Cell / Chemotaxis, Leukocyte / Leukemic Infiltration Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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