Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.

Schulte, Alexander; Günther, Hauke S; Martens, Tobias; Zapf, Svenja; Riethdorf, Sabine; Wülfing, Clemens; Stoupiec, Malgorzata; Westphal, Manfred; Lamszus, Katrin

Schulte, Alexander; Günther, Hauke S; Martens, Tobias; Zapf, Svenja; Riethdorf, Sabine; Wülfing, Clemens; Stoupiec, Malgorzata; Westphal, Manfred; Lamszus, Katrin.

Affiliation

Schulte A; Departments of Neurosurgery and Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Clin Cancer Res ; 18(7): 1901-13, 2012 Apr 01.

Article in En | MEDLINE | ID: mdl-22316604

Subject(s)

Epidermal Growth Factor/pharmacology; ErbB Receptors/genetics; Gene Amplification/drug effects; Glioblastoma/metabolism; Animals; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Glioblastoma/genetics; Glioblastoma/pathology; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Ligands; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasms, Experimental/genetics; Neoplasms, Experimental/metabolism; Neoplasms, Experimental/pathology; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Amplification / Glioblastoma / Epidermal Growth Factor / ErbB Receptors Limits: Animals / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2012 Document type: Article Affiliation country: Germany

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