Genes, Modifier/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Nerve Tissue Proteins/physiology; Protein Serine-Threonine Kinases/metabolism; tau Proteins/metabolism; Animals; Biomarkers/metabolism; Blotting, Western; Brain/cytology; Brain/metabolism; Cells, Cultured; Female; Gene Expression Profiling; HeLa Cells; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Intracellular Signaling Peptides and Proteins/genetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neurons/cytology; Neurons/metabolism; Oligonucleotide Array Sequence Analysis; Phosphorylation; Protein Serine-Threonine Kinases/antagonists & inhibitors; Protein Serine-Threonine Kinases/genetics; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Real-Time Polymerase Chain Reaction; Reelin Protein; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrosine/metabolism; tau Proteins/genetics