Restoration of synaptic plasticity and learning in young and aged NCAM-deficient mice by enhancing neurotransmission mediated by GluN2A-containing NMDA receptors.

Kochlamazashvili, Gaga; Bukalo, Olena; Senkov, Oleg; Salmen, Benedikt; Gerardy-Schahn, Rita; Engel, Andreas K; Schachner, Melitta; Dityatev, Alexander

Kochlamazashvili, Gaga; Bukalo, Olena; Senkov, Oleg; Salmen, Benedikt; Gerardy-Schahn, Rita; Engel, Andreas K; Schachner, Melitta; Dityatev, Alexander.

Affiliation

Kochlamazashvili G; Zentrum für Molekulare Neurobiologie Hamburg, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

J Neurosci ; 32(7): 2263-75, 2012 Feb 15.

Article in En | MEDLINE | ID: mdl-22396402

Subject(s)

Aging/physiology; Learning/physiology; Neural Cell Adhesion Molecules/deficiency; Neuronal Plasticity/physiology; Receptors, N-Methyl-D-Aspartate/physiology; Synapses/metabolism; Synaptic Transmission/physiology; Age Factors; Aging/genetics; Animals; Cycloserine/pharmacology; Hippocampus/metabolism; Hippocampus/pathology; Hippocampus/physiology; Long-Term Potentiation/physiology; Male; Mice; Mice, Knockout; Neural Inhibition/physiology; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Synaptic Transmission/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Aging / Receptors, N-Methyl-D-Aspartate / Synaptic Transmission / Neural Cell Adhesion Molecules / Learning / Neuronal Plasticity Limits: Animals Language: En Journal: J Neurosci Year: 2012 Document type: Article Affiliation country: Germany Country of publication: United States

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