Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

Langelueddecke, Christian; Jakab, Martin; Ketterl, Nina; Lehner, Lukas; Hufnagl, Clemens; Schmidt, Sabine; Geibel, John P; Fuerst, Johannes; Ritter, Markus

Langelueddecke, Christian; Jakab, Martin; Ketterl, Nina; Lehner, Lukas; Hufnagl, Clemens; Schmidt, Sabine; Geibel, John P; Fuerst, Johannes; Ritter, Markus.

Affiliation

Langelueddecke C; Institute of Physiology and Pathophysiology, Paracelsus Medical University, Salzburg, Austria.

Cell Physiol Biochem ; 29(1-2): 75-86, 2012.

Article in En | MEDLINE | ID: mdl-22415077

Subject(s)

AMP-Activated Protein Kinases/chemistry; Aminoimidazole Carboxamide/analogs & derivatives; Hypoglycemic Agents/pharmacology; Insulin/metabolism; Metformin/pharmacology; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Ribonucleotides/pharmacology; AMP-Activated Protein Kinases/metabolism; Aminoimidazole Carboxamide/pharmacology; Animals; Apoptosis/drug effects; Calcium/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Glucose/pharmacology; Insulin Secretion; Insulinoma/physiopathology; KATP Channels/metabolism; Membrane Potentials/drug effects; Phosphorylation; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Ribonucleotides / AMP-Activated Protein Kinases / Aminoimidazole Carboxamide / Hypoglycemic Agents / Insulin / Metformin Limits: Animals Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2012 Document type: Article Affiliation country: Austria

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