Resistance of Sézary cells to TNF-&#945;-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression.

Akilov, Oleg E; Wu, Mei X; Ustyugova, Irina V; Falo, Louis D; Geskin, Larisa J

Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression.

Akilov, Oleg E; Wu, Mei X; Ustyugova, Irina V; Falo, Louis D; Geskin, Larisa J.

Affiliation

Akilov OE; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15213, USA. akilovoe@upmc.edu

Exp Dermatol ; 21(4): 287-92, 2012 Apr.

Article in En | MEDLINE | ID: mdl-22417305

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Apoptosis/drug effects; Membrane Proteins/metabolism; Receptors, Tumor Necrosis Factor, Type I/metabolism; Sezary Syndrome/metabolism; Sezary Syndrome/pathology; Tumor Necrosis Factor-alpha/pharmacology; Aged; Aged, 80 and over; Apoptosis Regulatory Proteins/genetics; Female; Humans; Immunohistochemistry; Male; Membrane Proteins/genetics; Middle Aged; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reactive Oxygen Species/metabolism; Receptors, Tumor Necrosis Factor, Type II/metabolism; Sezary Syndrome/etiology; Signal Transduction; Up-Regulation

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sezary Syndrome / Tumor Necrosis Factor-alpha / Apoptosis / Receptors, Tumor Necrosis Factor, Type I / Apoptosis Regulatory Proteins / Membrane Proteins Type of study: Etiology_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2012 Document type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google