Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation.

Yoo, Ki-Chun; Yoon, Chang-Hwan; Kwon, Dongwook; Hyun, Kyung-Hwan; Woo, Soo Jung; Kim, Rae-Kwon; Lim, Eun-Jung; Suh, Yongjoon; Kim, Min-Jung; Yoon, Tae Hyun; Lee, Su-Jae

Yoo, Ki-Chun; Yoon, Chang-Hwan; Kwon, Dongwook; Hyun, Kyung-Hwan; Woo, Soo Jung; Kim, Rae-Kwon; Lim, Eun-Jung; Suh, Yongjoon; Kim, Min-Jung; Yoon, Tae Hyun; Lee, Su-Jae.

Affiliation

Yoo KC; Laboratory of Molecular Biochemistry, Department of Chemistry, Hanyang University, Seoul, Republic of Korea.

Int J Nanomedicine ; 7: 1203-14, 2012.

Article in En | MEDLINE | ID: mdl-22419868

Subject(s)

Apoptosis/drug effects; Reactive Oxygen Species/metabolism; Titanium/pharmacology; bcl-2-Associated X Protein/metabolism; fas Receptor/metabolism; Caspases/metabolism; Cell Line; Humans; Membrane Potential, Mitochondrial/drug effects; Particle Size; RNA, Small Interfering/metabolism; Titanium/chemistry; Up-Regulation/drug effects; bcl-2-Associated X Protein/chemistry; bcl-2-Associated X Protein/genetics; fas Receptor/genetics

Key words

Bax activation; Fas upregulation; TiO2; apoptotic cell death; caspase activation; mitochondrial membrane potential loss; reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Titanium / Reactive Oxygen Species / Apoptosis / Fas Receptor / Bcl-2-Associated X Protein Limits: Humans Language: En Journal: Int J Nanomedicine Year: 2012 Document type: Article Country of publication: New Zealand

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